May K. = [meɪ keɪ] (may_k) wrote,
May K. = [meɪ keɪ]
may_k

Protein Art: CDK5-P25 Complex

Dear readers of my blog,


I have to apologize for not being active for a while! I have received many great protein orders and little by little I am working on their realization. But unfortunately, I have a quite tough time this year as the final countdown of my PhD began. I will make up for the missing posts as soon as I can. Thank you for your understanding and patience! Here is a small reward:


Protein Data Bank ID: 1H4L

Protein Name: CDK5-P25 Complex

Organism: Homo sapiens

Title of Drawing: “Baby Dragon Playing with a Toy House




Cyclin-dependent kinase 5 (CDK5) is an enzyme which triggers the phosphorylation of a key protein of the reelin signaling pathway. Via this pathway CDK5 is involved in neuronal migration and positioning. For its activation CDK5 needs a cofactor, p35 (a fragment of p35 called p25 is shown in the bottom part of this drawing). Recent studies have shown that CDK5 is required already early on during brain development [1].

Similar to ‘playing games’, CDK5 is necessary for a proper development of children’s brain. This baby dragon playing with his toy house illustrates these connections.
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