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Protein Art: IκBα [Mar. 24th, 2012|12:18 am]
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Protein Data Bank ID: 1NFI
Protein Name: Ankyrin Repeat Domain of IκBα
Organism: Escherichia coli
Title of Drawing: "Five Seals"

I know, I’m a little late. But I don't want to miss this post as March 22. was the International Day of Seals. So here are the seals based on the IκBα protein, which, by the way, has been suggested by Diego, a guest of my blog.


IκBα belongs to the family of proteins which can inhibit the nuclear factor NF-κB. Therefore, first, it is important to understand the function of the latter protein. NF-κB is a transcription factor, meaning that it can go to the nucleus and bind DNA thereby controlling the transcription of special genes. This translocation to the nucleus requires some activating processes. In the case of NF-κB activation happens upon stress such as irradiation, free radicals, bacterial and viral intrusion, etc. This leads to a specific response helping the cell to overcome these stress conditions. In an unstressed situation NF-κB is inactive. IκBα is responsible for the inactivation of NF-κB by binding and sequestering it in the cytoplasm, thereby preventing its translocation to the nucleus. This inhibition is necessary to avoid chronic activation of NF-κB which might lead to cancer. It is the here shown ankyrin repeat domain of IκBα by which it masks the nuclear localization signals domain of NF-κB. Generally, the ankyrin repeat domain is responsible for protein-protein interactions and can be found in many different proteins.
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Comments:
[User Picture]From: roman_kr
2012-03-24 03:06 am (UTC)

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Здорово!!!
А можно теперь что-нибудь с теннисной ракеткой или на лыжах???
[User Picture]From: may_k
2012-03-24 09:01 am (UTC)

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буду искать:)
[User Picture]From: alleukemist
2012-03-24 04:15 am (UTC)

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That's a really nice one.
[User Picture]From: may_k
2012-03-24 09:01 am (UTC)

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Thanks!)
[User Picture]From: miljushka
2012-03-24 08:51 am (UTC)

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Очень здорово! а ты не пробовала свои картинки посылать на конкурсы? Периодически ищут же чтобы и научно и красиво. По-моему с такой оригинальной идеей есть хороший шанс на победу.
[User Picture]From: may_k
2012-03-24 09:04 am (UTC)

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Спасибо!:) Ага, как раз с таких конкурсов я и решила начать. И даже дважды уже занимала второе место)).
[User Picture]From: saint_dragon
2012-04-03 08:01 pm (UTC)

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Здорово как ;-) Я даже не подозревала, что белки такие чудные бывают.
[User Picture]From: ratamaque
2012-05-02 12:32 pm (UTC)

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Поздравляю с днем рождения!
[User Picture]From: may_k
2012-05-02 02:55 pm (UTC)

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Большое спасибо!:)
[User Picture]From: kozlenkoa
2012-11-03 07:26 am (UTC)

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О, Вас, я видел, It's Okay To Be Smart прорекламировал: http://www.itsokaytobesmart.com/post/34870857855/may-k-protein-art
Я его постоянно листаю, позитивный блог у него, очень славный.
[User Picture]From: may_k
2012-11-04 12:40 pm (UTC)

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Ой, круто!:)Спасибо за инфу, а то я никак не могла понять, откуда такой прирост посетителей за последние дни.